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Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated gene expression in t(8;21) acute myeloid leukemia

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Frontiers of Medicine 2021, Volume 15, Issue 4,   Pages 608-620 doi: 10.1007/s11684-021-0836-7

Abstract: t(8;21)(q22;q22) acute myeloid leukemia (AML) is a highly heterogeneous hematological malignancy withleukemic myeloblast populations (CD34 CD117 and CD34 CD117 ) were previously identified in t(8;21) AMLwe examined the impact of CD34 CD117 /CD34 CD117 myeloblast-associated gene expression on t(8;21) AMLIn this study, 85 patients with t(8;21) AML were enrolled.CD117 myeloblast-associated gene expression may provide new clinically prognostic markers for t(8;21) AML

Keywords： t(8     21)(q22     q22) AML     CD34+CD117dim/ CD34+CD117bri cell population    

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Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

Frontiers of Structural and Civil Engineering 2014, Volume 8, Issue 4,   Pages 448-455 doi: 10.1007/s11709-014-0262-x

Abstract: Rock mass classification system is very suitable for various engineering design and stability analysis. classification method is confirmed by Japan Highway Public Corporation that this method can figure out either strength or deformability of rock mass, further appropriating the amount of rock bolts, thickness of shotcrete, and size of pitch of steel ribs just after the blasting procedure. Based on these advantages of method, in this study, according to data of five deep and long tunnels in Iran, two equations for estimating the value of method from and classification systems were developed. These equations as a new method were able to optimize the support system for and classification systems. From classification and its application in these case studies, it is pointed out that the method for the design of support systems in underground working is more reliable than the and classification systems.

Keywords： JH classification     Q and RMR classification     new method    

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An approach for evaluating fire resistance of high strength Q460 steel columns

Wei-Yong WANG, Guo-Qiang LI, Bao-lin YU

Frontiers of Structural and Civil Engineering 2014, Volume 8, Issue 1,   Pages 26-35 doi: 10.1007/s11709-014-0239-9

Abstract: To develop a methodology for evaluating fire resistance of high strength Q460 steel columns, the loadbearing capacity of high strength Q460 steel columns is investigated.evaluating load bearing capacity of mild steel columns at room temperature is extended to high strength Q460steel columns with due consideration to high temperature properties of high strength Q460 steel.The critical temperature of high strength Q460 steel column is presented and compared with mild steel

Keywords： high strength Q460 steel     load bearing capacity     temperature    

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AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 248-262 doi: 10.1007/s11684-012-0206-6

Abstract:

The AML1-ETO fusion transcription factor is generated by the t(8;21) translocation, which is presentin approximately 4%–12% of adult and 12%–30% of pediatric acute myeloid leukemia (AML) patientsBoth human and mouse models of AML have demonstrated that AML1-ETO is insufficient for leukemogenesis-ETO to induce AML in vivo.We also discuss potential therapeutic strategies for t(8;21) positive AML that involve targeting the

Keywords： AML1-ETO     mouse model     leukemia     t(8     21)     pathway hits     mutation     hematopoiesis     Kasumi-1     CD34+    

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Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 388-397 doi: 10.1007/s11684-018-0624-1

Abstract: Collaboration of c-KIT mutations with AML1–ETO (AE) has been demonstrated to induce t(8; 21) acute myeloidleukemia (AML).therapies designed to eliminate AE and c-KIT oncoproteins may facilitate effective treatment of t(8; 21) AMLfeatures activity against tumor cells harboring c-KIT mutations, whereas oridonin can induce t(8; 21) AMLTherefore, studies should explore the efficacy of combination therapy with oridonin and HHT in t(8; 21) AML

Keywords： AML1–ETO     c-KIT     homoharringtonine     oridonin     t(8     21) AML     synergistic effect    

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R158Q and G212S, novel pathogenic compound heterozygous variants in of Gitelman syndrome

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 932-945 doi: 10.1007/s11684-022-0963-9

Abstract: The prediction of mutant protein showed that p.R158Q and p.G212S could alter protein’s three-dimensionalMeanwhile, we conducted a compound heterozygous model—Ncc R156Q/G210S mice corresponding to human NCCR158Q/G212S.The hydrochlorothiazide test showed a loss of function of mutant Ncc in NccR156Q/G210S miceThese findings indicated that R158Q and G212S variants of SLC12A3 were pathogenic variants of

Keywords： Gitelman syndrome     mouse model     compound heterozygous     hypokalemia     Slc12a3    

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Simultaneous Screening of 733 Pesticide Residues in Fruits and Vegetables by a GC/LC-Q-TOFMS Combination Article

Guofang Pang, Qiaoying Chang, Ruobin Bai, Chunlin Fan, Zijuan Zhang, Hongyuan Yan, Xingqiang Wu

Engineering 2020, Volume 6, Issue 4,   Pages 432-441 doi: 10.1016/j.eng.2019.08.008

Abstract: chromatography (LC)– and gas chromatography (GC)–quadru pole-time-of-flight mass spectrometry (Q-TOFMSstandard materials as references through one sample preparation and the combination of GC/LC–Q-TOFMStechnique, the combination technique shows an improvement of 51.1% (GC–QTOFMS) and 39.6% (LC–Q-TOFMS

Keywords： Pesticide multi-residues     GC–Q-TOFMS      LC–Q-TOFMS     Accurate mass database      Spectra library      Fruits and    

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A New Type of Q-switched and Frequency-doubling Green Laser

Chen Fei,Huo Yujing,He Shufang,Feng Lichun

Strategic Study of CAE 2000, Volume 2, Issue 4,   Pages 39-42

Abstract:

A new type of LD pumped Nd： YV04- KTP Q-switched green laser is demonstrated.By using the KTP crystal as both an electro-optic Q-switcher and a frequency-doubling crystal in type

Keywords： KTP     green laser     electro-optic Q-switcher     frequency-doubling    

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Application research of Q&P concept in hot rolled AHSS production

Yuan Guo,Kang Jian,Zhang He,Li Yunjie,Hu Hongling and Wang Guodong

Strategic Study of CAE 2014, Volume 16, Issue 1,   Pages 59-65

Abstract: industry，the development of advanced high strength steel obtained using the quenching and partitioning （Q&In the present work，the application of Q&P concept during hot rolling was investigated for wide useof Q&P process on the conventional hot rolling production line.It was shown that introducing thermo-mechanical treatment during the conventional Q&P process wasThe feasibility of producing the hot rolled Q&P steel（DQ（direct quenching）&P steel）was determined

Keywords： advanced high strength steel     Q&P     DQ&P     hot rolling     retained austenite    

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On-Line Supervisory Technology for Q-Factor in the Optical Supervisory Channel of Optical Transport Network

Tang Yong,Sun Xiaohan,Zhang Mingde,Ding Dong

Strategic Study of CAE 2001, Volume 3, Issue 12,   Pages 71-75

Abstract: Basing on the one-to-one correspondence of Q-factor with bit-error-ratio (BER) in data communicationsystems, an on-line supervisory scheme for Q-factor of signals in OSC is presented, and the supervisorymodule by a digital signal processor (DSP) approach is designed to implement on-line supervision for Q-factor

Keywords： optical transport network (OTN)     optical supervisory channel (OSC)     OAM     Q-factor supervision    

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A rare case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation

Xiaofeng Shi, Rong Ba, Haiyan You, Qian Jiang, Jiansong Huang, Jianhua Mao, Lanxiu Han, Shuo Zhang, Qin Zhuang, Xianqiu Yu, Lixia Wang, Yun Wang, Dongya Li, Wei Zhu, Yong Zhang, Yan Zhu, Xiaodong Xi

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 324-329 doi: 10.1007/s11684-017-0558-z

Abstract: At present, only one case of SLVL with t(8;14)(q24;q32) translocation has been reported.study, we report a case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) chromosome translocation that we inclined to SLVL with a prolymphocytic transformation.The immunophenotypes showed CD19+, CD20+, HLA-DR+, CD22+,The karyotype showed complex abnormality: 46XX,+3,−10, t(8;14)(q24;q32)[11]/46XX[9].

Keywords： splenic lymphoma with villous lymphocytes     splenic marginal zone lymphoma     transformation     chromosome translocation    

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Hot deformation behavior of a novel bimetal consisting of BTW1 and Q345R characterized by processing

Pengtao LIU, Lifeng MA, Weitao JIA, Tao WANG, Guanghui ZHAO

Frontiers of Mechanical Engineering 2019, Volume 14, Issue 4,   Pages 489-495 doi: 10.1007/s11465-019-0554-x

Abstract: Only a few studies have been conducted on the flow behavior of the novel BTW1/Q345R bimetal, which isIn this work, compression tests were conducted on BTW1/Q345R bimetal at a temperature range of 950 °CThe computed apparent activation energy of the BTW1/Q345R bimetal was 360 kJ/mol, and processing mapsrelationship revealed that work hardening exerted a dominant effect on the thermal deformation of the BTW1/Q345RResults showed that thermal deformation of the BTW1/Q345R bimetal should proceed when the temperature

Keywords： BTW1/Q345R bimetal     constitutive equation     processing map     work hardening    

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A deep Q-learning network based active object detection model with a novel training algorithm for service Research Article

Shaopeng LIU, Guohui TIAN, Yongcheng CUI, Xuyang SHAO

Frontiers of Information Technology & Electronic Engineering 2022, Volume 23, Issue 11,   Pages 1673-1683 doi: 10.1631/FITEE.2200109

Abstract: The DQN model is designed to fit the Q-values of various actions, and includes state space, feature extraction

Keywords： Active object detection     Deep Q-learning network     Training method     Service robots    

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Development of barium@alginate adsorbents for sulfate removal in lithium refining

Lisa Xu, Kaifei Chen, George Q. Chen, Sandra E. Kentish, Gang (Kevin) Li

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 1,   Pages 198-207 doi: 10.1007/s11705-020-1968-z

Abstract: The demand for lithium has been steadily growing in recent years due to the boom of electric cars. High purity lithium is commonly used in the manufacture of battery grade lithium electrolyte. Sulfate residuals originating from acid leaching of lithium ores must be limited to below 20 mg·L during refining. There are methods to remove sulfate such as membrane processing and chemical precipitation using barium salts. However, membrane separation is unable to achieve the required purity while chemical precipitation often causes secondary contamination with barium and requires extra filtration processes that lead to increased processing costs. In this study, we developed a polymeric matrix entrapped with barium ions as a novel adsorbent to selectively adsorb sulfate in aqueous solutions. The adsorbent was prepared by dropwise injection method where alginate droplets were crosslinked with barium to form hydrogel microcapsules. In a typical scenario, the microcapsules had a diameter of 3 mm and contained 5 wt-% alginate. The microcapsules could successfully reduce sulfate concentration in a solution from 100 to 16 mg·L , exceeding the removal target. However, the microcapsules were mechanically unstable in the presence of an excess amount of sulfate. Hence, calcium ions were added as a secondary crosslinking agent to improve the integrity of the microcapsules. The two-step Ca/Ba@alginate microcapsules showed an exceptional adsorption performance, reducing the sulfate concentration to as low as 0.02 mg·L . Since the sulfate selective microcapsules can be easily removed from the aqueous system and do not result in secondary barium contamination, these Ca/Ba@alginate adsorbents will find applications in ultra-refining of lithium in industry.

Keywords： barium@alginate     microcapsules     dropwise injection     sulfate removal     lithium    

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Standard-independent I/Q imbalance estimation and compensation scheme inOFDM direct-conversion transceivers None

Fang-lin GU, Shan WANG, Wen-wu WANG

Frontiers of Information Technology & Electronic Engineering 2018, Volume 19, Issue 3,   Pages 388-397 doi: 10.1631/FITEE.1700003

Abstract: However, they suffer from a serious in- and quadrature-phase (I/Q) imbalance problem.The I/Q imbalance can severely limit the achievable operating signal-to-noise ratio (SNR) at the receiver(OFDM) receivers, and then propose a new I/Q imbalance compensation scheme.imbalance parameters, and then the I/Q imbalance is corrected in the frequency domain.The results show that the proposed I/Q imbalance compensation method can achieve bit error rate (BER)

Keywords： In- and quadrature-phase (I/Q) imbalance     Orthogonal frequency division multiplexing (OFDM)     Standard-independent    

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Title Author Date Type Operation

Clinical significance of CD34+CD117dim/CD34+CD117bri myeloblast-associated gene expression in t(8;21) acute myeloid leukemia

Xueping Li, Yuting Dai, Bing Chen, Jinyan Huang, Saijuan Chen, Lu Jiang

Journal Article

Development of a new method for RMR and Q classification method to optimize support system in tunneling

Asghar RAHMATI,Lohrasb FARAMARZI,Manouchehr SANEI

Journal Article

An approach for evaluating fire resistance of high strength Q460 steel columns

Wei-Yong WANG, Guo-Qiang LI, Bao-lin YU

Journal Article

AML1-ETO driven acute leukemia: insights into pathogenesis and potential therapeutic approaches

Megan A. Hatlen, Lan Wang, Stephen D. Nimer

Journal Article

Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

Journal Article

R158Q and G212S, novel pathogenic compound heterozygous variants in of Gitelman syndrome

Journal Article

Simultaneous Screening of 733 Pesticide Residues in Fruits and Vegetables by a GC/LC-Q-TOFMS Combination

Guofang Pang, Qiaoying Chang, Ruobin Bai, Chunlin Fan, Zijuan Zhang, Hongyuan Yan, Xingqiang Wu

Journal Article

A New Type of Q-switched and Frequency-doubling Green Laser

Chen Fei,Huo Yujing,He Shufang,Feng Lichun

Journal Article

Application research of Q&P concept in hot rolled AHSS production

Yuan Guo,Kang Jian,Zhang He,Li Yunjie,Hu Hongling and Wang Guodong

Journal Article

On-Line Supervisory Technology for Q-Factor in the Optical Supervisory Channel of Optical Transport Network

Tang Yong,Sun Xiaohan,Zhang Mingde,Ding Dong

Journal Article

A rare case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation

Xiaofeng Shi, Rong Ba, Haiyan You, Qian Jiang, Jiansong Huang, Jianhua Mao, Lanxiu Han, Shuo Zhang, Qin Zhuang, Xianqiu Yu, Lixia Wang, Yun Wang, Dongya Li, Wei Zhu, Yong Zhang, Yan Zhu, Xiaodong Xi

Journal Article

Hot deformation behavior of a novel bimetal consisting of BTW1 and Q345R characterized by processing

Pengtao LIU, Lifeng MA, Weitao JIA, Tao WANG, Guanghui ZHAO

Journal Article

A deep Q-learning network based active object detection model with a novel training algorithm for service

Shaopeng LIU, Guohui TIAN, Yongcheng CUI, Xuyang SHAO

Journal Article

Development of barium@alginate adsorbents for sulfate removal in lithium refining

Lisa Xu, Kaifei Chen, George Q. Chen, Sandra E. Kentish, Gang (Kevin) Li

Journal Article

Standard-independent I/Q imbalance estimation and compensation scheme inOFDM direct-conversion transceivers

Fang-lin GU, Shan WANG, Wen-wu WANG

Journal Article